Ear hair cell regeneration 2018, The drugs stimulated supporting cell proliferation and differentiation into hair cells. Citation Report Citation Report 19 Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss. Hidden hearing loss is usually linked to cochlear synaptopathy — damage to the synapses between inner hair cells in the cochlea and the auditory nerve. Abstract Adult human inner ear hair cells have extremely limited regenerative ability, and the inaccessibility of human inner ear tissue makes studying regeneration challenging. In this study, we examined whether 5-azacytidine (5-aza) could induce hair cell-like differentiation using our previously established human utricular cell (HUC) line. . Viral vectors carrying a protective gene are delivered into the fluid cavity of the cochlea, where they transfect hair cells and ultimately protect hearing (a). Chen et al. 0 34 Jul 1, 2010 · This work has shown that the Notch signaling pathway, the Atoh1/Hes signaling cascade, the stem cell marker Sox2, and some of the unconventional myosin motor proteins are utilized to regulate distinct steps in inner ear development. May 2, 2018 · Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. Oct 16, 2025 · Their functional scope encompasses the entire ear anatomy—from the external ear cartilage to the inner ear hair cells—providing tailored therapeutic strategies for challenging conditions such as microtia, otitis media, and sensorineural hearing loss. The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and therefore, hair cell loss and subsequent hearing loss are permanent in humans. In consequence of that, hair cell regeneration is limited and hearing loss is permanent in adult mammals. Conversely, functional hair cell regeneration can be observed in non-mammalian vertebrate species like birds and fish. The regeneration of hair cells is achieved by the transduction of supporting cells of the flat epithelium using a viral vector carrying a regenerative gene (b). show that overexpression of Gfi1 and Pou4f3 simultaneously with Atoh1 enhances the efficiency of cochlear hair cell generation and promotes the functional maturation of new hair cells, representing a step forward in generating functional hair cells in the mammalian cochlea. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within b … Jun 13, 2018 · Gene and stem cell therapies for hearing loss. Thus far, therapeutic trials in animal models targeting vestibular loss associated with genetic diseases have yielded variable and partial results, and the functional identity and quantity of HCs required to restore 3 days ago · Abstract Adult human inner ear hair cells have extremely limited regenerative ability, and the inaccessibility of human inner ear tissue makes studying regeneration challenging. 0. Sep 24, 2024 · Here, we show substantial regeneration of hair cells in a mouse model of vestibular damage by treatment with a combination of glycogen synthase kinase 3β and histone deacetylase inhibitors. Advances in Experimental Medicine and Biology, 2019, , 17-36. Three rows of outer hair cells (top) and a single row of inner hair cells (bottom) are visible, illustrating the precise cellular organization required for sound detection Vestibular dysfunction constitutes a major medical concern, and regeneration of hair cells (HCs) is a primary target of gene therapy aimed at restoring vestibular functions. In stem cell therapy Aug 1, 2018 · Unfortunately, mammals have lost their ability to self-repair damaged hair cells or to regenerate new inner ear hair cells. The discovery of avian cochlear hair cell regeneration in the late 1980s and the concurrent development of new techniques in molecular and developmental biology It’s called “hidden” because traditional hearing exams often don’t detect it. 3 days ago · Sensory hair cells of the mouse inner ear stained with phalloidin to highlight actin-rich structures called stereocilia, which are arranged in bundles forming the mechanosensory organelle of the inner ear sensory cells.


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